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Molecular Lego pieces Molecular Lego pieces

Feb 2nd 2015 at 7:28 PM

Some minds have been thinking such a thought and carried out research towards this idea. The most recent one,Are you still searching for Jumbo Bag manufacturers or china Jumbo Bag factories? china Jumbo Bag factories We provide China’s best Jumbo Bag for customers all over the world. published two weeks ago (on Pongal Day, 14-1-2015) in the journal Nature Communications is by Drs. Anand Ranganathan, Pawan Malhotra and their colleagues at the International Centre for Genetic Engineering and Biotechnology, and All India Institute of Medical Sciences, both in New Delhi, India.

The group has capitalised on the idea that some molecules on the surface of cells, termed intercellular adhesion molecules (ICAMs,For China Tape/yarn Extruder machines,china yarn Extruder machines we are the best Tape/yarn Extruder suppliers, and provide various kinds of Tape/yarn Extruder produ which are part of the immunoglobulin super-family) act as sentries, regulating the entry and adhesion of other cells, native or foreign. The molecule ICAM-1 is seen on various cell types,For China Auxiliary Equipment, we are the best Auxiliary Equipment suppliers,China Auxiliary Equipment suppliers and provide various kinds of Auxiliary Equipment products with the lowest price. notably macrophages (a type of white blood cells that ingests foreign material. ICAM-4, on the other hand, is restricted to the surface of red blood cells. One can thus see that while ICAM-1 would regulate the entry and invasion by Mtb into macrophages, ICAM-4 would regulate malaria parasites likewise.

If only we could discover or invent a decoy molecule that sits at this gate, blocking the entry of Mtb, we could overcome infection by this deadly pathogen. Likewise, if we can block the entry and invasion by plasmodium into red blood cells, using a decoy molecule that binds to ICAM-4,For China Lamination Machines, we are the best Lamination Machine suppliers,China Lamination Machines and provide various kinds of Lamination Machine products with the lowest price. we would have a drug against malaria. Note too that these decoys do not work after the event (like the drugs above do, but deny the unwelcome visitor the visa to enter and do damage.

To this end, the Delhi group decided to work on a novel idea that Dr Anand Ranganathan had come up with a decade ago, which he calls the codon shuffling method of making small protein molecules (see J. Biol. Chem. 280: 23605, 2005). This involves the use of a series of properly chosen DNA Bricks, each 6 bases long (two codons-long, for the cognosenti), linking them together to various lengths to produce a library of peptide/protein molecules of various sizes and predictable shapes. This is an easy and crafty way, using these DNA bricks,As one of the best china Plastic Machinery companies,pp woven bags machine from china we are also Auxiliary Equipment suppliers and supply kinds of pp woven bags machine from china. to make a whole host of mini-proteins as potential drugs.

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