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Dec 22nd 2015 at 8:43 PM

Garcinia Cambogia G3000 is a rare disease of accelerated aging. HGPS patients fascinate clinicians and the public alike, because of their dramatic appearance and tragically shortened lives. However, analysis has progressed rapidly and a cure for progeria is now thought of potential.HGPS is caused by mutations in the Lamin A (LMNA) gene, resulting in deletion of amino acids inside the protein prelamin A. This protein is a element of the nuclear membrane, providing structural scaffolding for the cell nucleus.A consequence of the abnormal nuclear membrane is increased DNA damage and reduced cell division. The same mechanisms seen in cells throughout the traditional ageing process.

Classical Hutchinson Gilford progeria syndrome follows an autosomal dominant pattern of expression i.e. solely one copy of the mutant gene is required to cause the disease. Almost all cases result from a de novo (new) mutations within the egg, sperm or developing foetus. Therefore HGPS does not run in families and the chance of getting affected siblings is considered low.HGPS is very rare with an incidence of around one in six million newborns, with equal occurrence in ladies and boys.The clinical diagnosis of HGPS relies on recognition of common clinical features (see below) and molecular detection of mutations in the LMNA gene. Mean age of diagnosis is two years old.Primarily based on statistical estimates the Progeria Analysis Foundation believe there are undiagnosed youngsters with the condition and have launched a campaign named 'Find the Other 150'.Children with Hutchinson Gilford progeria syndrome look healthy at birth but show accelerated aging from around eighteen months. The vary and severity of symptoms in HGPS is variable, however include.>>

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