Drugs that increase energy expenditure
The thermogenesis can be achieved by activating SNS central or peripheral stimulation atypical beta-3 receptor. The only thermogenic therapeutic strategy evaluated in short-and long-term (6 months) or ephedrine combined with caffeine. However, this combination is not currently available for the treatment of obesity.
Other dietary supplements and herbal products
Egger and colleagues evaluated the available data on supplements for weight reduction, including Garcinia cambogia, capsaicin, caffeine and guarana, L-carnitine, chitosan, chromium picolinate, Fucus vesiculosus, Ginkgo biloba, pectin, grape seed extract, lecithin, isoflavones and St. John's wort. Many experimental studies had shortcomings. We found some benefit with capsaicin, caffeine and fiber but tests were inconclusive. Current data do not support any of these products promotes weight loss.
Future medical therapies
The hormone ghrelin appears to play a role in weight regulation in the long term.
In a study in which ghrelin was administered by intravenous infusion, increased energy consumption by 28% in a single meal compared with placebo. Moreover, 31 day fat loss cure review Programs their levels are very low in subjects who underwent gastric bypass surgery, which could additionally influence weight loss in these patients.
Therefore, antagonists of ghrelin may have a potential role in the treatment of obesity.
Another study therapeutic target in the endocannabinoid system. Rimonabant is a cannabinoid receptor antagonist CB1. Preliminary results from 2 clinical studies indicate that patients treated with 20 mg of rimonabant lost 15 pounds more than those assigned to placebo, and experienced a significant improvement in waist circumference, levels of lipoprotein and low density, triglycerides , adiponectin and leptin, C-reactive protein and insulin sensitivity. After one year, 44% of the participants obtained a weight loss> 10%.Health product
Bariatric procedures for weight reduction share 2 characteristics: intestinal malabsorption and gastric restriction. Procedures based on malabsorption include the rearrangement of the small intestine to reduce the functional length or efficiency of the mucosa for nutrient absorption. The jejunoileal bypass is no longer used because it is associated with liver failure, cirrhosis, oxalate kidney stones, enteritis, arthritis and metabolic deficit.
The derivation of the bilio-pancreatic secretion into the distal ileum 50 cm distal gastrectomy plus may be associated with protein-energy malnutrition, bone disease and soluble vitamins, calcium, iron and vitamin B12.
Restrictive procedures involve the formation of a small stomach pouch to reduce food intake capacity and include gastroplasty, gastric banding and gastric bypass. Many surgeons have abandoned the gastroplasty because the results of randomized trials showed less weight loss compared with gastric bypass Roux-en-Y. The adjustable gastric band procedure can be placed laparoscopically. However, it is associated with side effects such as nausea, vomiting, heartburn, abdominal pain or band slippage, or insufficient weight loss. Gastric bypass is the surgical procedure of choice because it produces greater weight loss and the latter is kept in excellent shape long term.
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