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Why fails the bypass?

May 21st 2014 at 9:14 PM

An international team of scientists reveals why it fails in many patients this surgery. Read the ...

The bypass is done to restore blood flow is blocked by stenosis or occlusion of a coronary artery of the heart. Sometimes though the surgery is not successful.

Scientists report on Form «Science Translational Medicine», that one mechanism by which induced thickening in the walls of veins used for bypass, which is why it often fails this surgery. Because of this thickening is often hindered the flow of blood, so the patient needs to undergo a new bypass.  

Why fails the bypass?
The vein is usually used to bypass the saphenous vein extending along the leg. Doctors choose this because it is great in size, and is easy to remove a part for use in the coronary artery.

The vein is then reshaped to become more "blood", as the veins have thinner walls than what normal arteries thus withstand lower blood pressures. However, anything can go wrong in remodeling, therefore the wall of the vein to become too thick and thus prevent re-flow of blood.

The researchers conducted their study in mice that had undergone bypass. Examining the grafted veins, observed that responsible for the thickening of the veins is a procedure called endothiliomesenchymatiki transition.

The researchers also looked at human veins of failed bypass, noting that existed in these signs of this process. "Now that we understand the mechanism that causes the constriction, we can find therapeutic strategies to fight it," says study leader.

Experts argue that a possible treatment option is the drug Losartan, administered for the treatment of hypertension. But further studies in the laboratory before being applied to humans.

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