Antidepressant medications were reduced and discontinued for a week before the start of TMS.
The TMS treatment was associated with a significant improvement in mood, including a 41% reduction in HAM-D score and 40% in the BDI.
Five patients could be classified as responders, defined by a reduction of at least 50% of the HAM-D after application of MTS.
The improvement in the BDI scale in 10 patients was still statistically significant after 3 months of application of EMT. Free News HERE http://healthandfitnessblogs2014.blogspot.com/
Although this was an open study, without the use of placebo, all patients were resistant to drug therapy, in which two periods of 4 weeks with antidepressants had resulted in failure
With TMS, all answered well without antidepressant.
Avery et al , in a study of real and placebo TMS over the left prefrontal cortex in the treatment of 6 patients with pharmacologically resistant depression used the following paradigms:
80% LM 10 Hz with 1,000 pulses in 10 sessions over a period of 16 days
The selected patients had had failed at least two different types of antidepressant.
Despite the small sample, the authors concluded that the improvement in the group receiving TMS (down from 10.5 in Hamilton scale) were significant.
Another finding of the study was an improvement in the subject's performance on neuropsychological tests after 10 days of treatment. In the study, there was still a patient in response to greater than one year after the use of TMS