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Refractory to conventional treatments

Nov 5th 2013 at 11:19 PM

There are factors, both intrinsic and extrinsic to the phenomenology of OCD, which are related to resistance and refractory to conventional treatments.

The predictors of inadequate response to conventional treatments found to date in scientific studies are early, the content of obsessive

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Compulsive symptoms (hoarding, sexual, religious, somatic) sensory phenomenon, greater severity of symptoms, insight poor, presence tics and co morbidities (personality disorders, borderline and paranoid; personality disorder)

Though some of these factors recur in several studies as factors of non-response, there is still no proof of a causal connection between some of them and treatment resistance

In addition, there are factors that possibly influence the response to treatment, but have not yet been demonstrated from scientific studies, such as chronic course of the disease, diagnosis of major depression and a family history of OCD.

Among the extrinsic factors to OCD which can interfere significantly in appropriate therapy can mention support and family functioning, with its repercussions in the maintenance of obsessive-compulsive symptoms.

However, it is also important to consider the constitutional characteristics of each individual, as the absorption capacity and the speed of metabolism of drugs and other factors that involve engagement with treatment.

Finally. One can not overlook the influence of the high costs associated with therapeutic modalities indicated in OCD. The term "family accommodation" can be explained as the involvement of family members in the patient's symptoms

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