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Phospholipid biosynthesis

Jul 14th 2014 at 12:12 AM

Phospholipid biosynthesis group PAP having signaling properties can go two ways. The biosynthesis de novo (predominant in the kidney and central nervous system) is the first step in the biosynthesis of the transfer of the acetyl group from coenzyme

A 2-hydroxyl-1-O-W-alkilglitsero phosphate catalyzed Under the effect of PAF-fosfogidrolazy fosfoefirnoy hydrolysis product of the received and to liberate hydroxyl at the 3-position of glycerol phosphocholine joins, in a portable form tsitidindifosfatholina enzyme-CDP-holinfosfotransfe Raza. Second biosynthetic pathway PAF

(in the predominant cells involved in the inflammatory response) can be initiated factors activating phospholipase A enzyme hydrolyses the ester bond between the carboxylic group of the fatty acids (arachidonic acid, C20: 4)

and glycerol 2-hydroxy-1-al-O kil-2-arahidonoilglitsero NW-phosphocholine with the release of the free acid (able to serve as a substrate for the biosynthesis hey kozanoidov) and lyso-PAF. To liberate the 2-hydroxyl in the glycerol lyso-PAF using acetyltransferase

further joins acetate using as the second substrate acetyl-CoA to form PAF. And allowing the existence of a third biosynthetic pathway PAF, starting with transatsilirovaniya reaction, ie carry-arachidonic acid-I-O-alkyl-2

arachidonoyl-glycero-3-phosphocholine on lizofosfolipidny acceptor to form a lyso-PAF. Synthesis of PAF lyso-PAF also may occur non-enzymatically by the transfer of acetyl residues acetylated proteins (albumin, apolipoprotein A-1), which is contacted with lyso-PAF.

Biosynthesis of PAF - strictly controlled process, including tissue-specific regulation of the activity of the corresponding enzymes to various factors. For example, the formation of PAF by endothelial cells stimulate thrombin,

vascular endothelial growth factor (VEGF), tumor necrosis factor alpha (TNFa), bacterial lipopolysaccharide wall hypoxia and inhibits nitric oxide. It is assumed that one of the causes of septic shock can serve as a dysregulation of Education PAF.

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