Studies with reduced EMT for use in the treatment of depression evident
Subsequent to study Paschal-Leone et al  George et al  found only a 20% decrease in score on the Hamilton scale after application of TMS over the left prefrontal cortex.
Pad berg et al  also found a small improvement (19% decrease in the Hamilton scale) after low frequency TMS and marginal effects after high-frequency TMS
These two studies used a smaller number of those who have been successful stimuli.
Look et al  found no difference between the groups that received sham TMS and real.
George et al , based on a placebo-controlled study, depressed patients randomly divided to receive for 2 weeks active TMS ( 800 pulses, 20 Hz, 80% LM) or 2 weeks of placebo TMS over the left prefrontal cortex
The mean score on the Hamilton scale decreased by 20% in the treatment group and increased by 12% in the placebo group.
The modest effect found in this study may be due to the smaller number of stimuli applied (800 per session) compared to others who have used 2,000 stimuli per day [Paschal-Leone et al, 1996
Trigg et al, 1999]. Pad berg et al , in a randomized, divided 24 patients with major depression pharmacologically resistant (at least three drugs) into three groups:
Placebo EMT, low frequency TMS (1 Hz) and high frequency (10Hz) Antidepressant medications were maintained at a stable dose.
The stimulation was performed over the left prefrontal cortex.