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Alexa Alene | alexaalene120

Dietary Supplements for Cholesterol Reduction

Dec 17th 2013 at 10:04 PM

Heart and blood vessel (cardiovascular) disease is the No. 1 killer of Americans, and study after study points to elevated cholesterol as a major contributor to the problem. Some authorities have indicated that for every one percentage point that cholesterol levels are reduced, the risk for cardiovascular disease is reduced by 2 points. The current conventional medical treatment is cholesterol-lowering prescription drugs, along with low saturated fat diets. Although these drugs do lower serum cholesterol, they also have potential side-effects. Consequently, it may make sense to work with your doctor in trying one or more of the following relatively risk-free dietary supplement approaches before taking drugs.

Artichoke extract

You may have enjoyed steamed or grilled artichokes dipped in butter, but this culinary treat also has medicinal properties. Aside from its well-established effects for promoting liver health and popular use in Europe for the treatment of mild indigestion (particularly following a high fat meal) artichoke leaf extract also has the ability to reduce total and LDL cholesterol, and the LDL/HDL ratio over 6 to 12 weeks of treatment. In one double-blind, placebo-controlled study, those using artichoke leaf extract experienced an 18.5% decrease in total cholesterol, compared to 8.6% in the placebo group. The LDL-cholesterol decreased 22.9% in the artichoke group and 6.3% for placebo; and LDL/HDL ratio showed a decrease of 20.2% in the artichoke group and 7.2% in the placebo group. i Other research has shown similar results, and artichoke extract may work better in people with higher cholesterol levels.ii Orally, artichoke extract might increase flatulence in some patients. The typical dose used in research is 1800-1920 mg per day in 2 to 3 divided doses.


Chromium supplementation has reduced total cholesterol,iii ivLDL cholesterolv vi and increased HDL cholesterolvii viii in double-blind and other controlled trials, although other trials have not found these effects.ix x One double-blind trial found that high amounts of chromium (500 mcg per day) in combination with daily exercise was highly effective, producing nearly a 20% decrease in total cholesterol levels in just 13 weeks.xi Not surprisingly, people with higher blood levels of chromium appear to be at lower risk for heart disease.xii

Inositol hexanicotinate

High amounts (several grams per day) of niacin lower cholesterol; an effect recognized in the approval of niacin as a prescription medication for high cholesterol.xiii At such intakes, however, acute symptoms (flushing, headache, stomachache) may be severe. In an attempt to avoid the side effects of niacin, alternative health practitioners increasingly use inositol hexaniacinate, recommending 500 to 1,000 mg, taken three times per day, instead of niacin.xiv xv This special form of niacin has been reported to lower serum cholesterol but so far has not been found to cause significant toxicity.xvi


Guggul, a mixture of substances taken from a plant, is an approved treatment for elevated cholesterol in India and has been a mainstay of the Ayurvedic approach to preventing atherosclerosis. One double-blind trial studying the effects of guggul reported that serum cholesterol dropped by 17.5%.xvii In another double-blind trial comparing guggul to the drug clofibrate, the average fall in serum cholesterol was slightly greater in the guggul group; moreover, HDL cholesterol rose in 60% of people responding to guggul, while clofibrate did not elevate HDL.xviii A third double-blind trial found significant changes in total and LDL cholesterol levels, but not in HDL.xix Guggul extract, providing 75 to 150 mg of guggulsterones daily, has been given in research 2 to 3 times daily for up to 8 weeks.

Plant Sterols & Stanols

Beta-sitosterol is a plant sterol. Plant sterols are natural substances found in small quantities in many fruits, vegetables, nuts, seeds, cereals, legumes, vegetable oils, and other plant sources. Research has demonstrated that taking beta-sitosterol orally significantly reduces total and low-density lipoprotein (LDL) cholesterol levels, but has little or no effect on high-density lipoprotein (HDL) cholesterol levels. LDL is considered to be the “bad cholesterol”, while HDL is considered to be the “good cholesterol”. The way it works is that beta-sitosterol blocks cholesterol absorption in the intestines, which in turn results in lowered LDL cholesterol in the bloodstream. For the most part, the consumption of about 2 grams daily has been reported to decrease LDL cholesterol levels 9% to 20%, although usual doses have ranged between 800 mg to 6 grams per day and given before meals. Beta-sitosterol is typically given in conjunction with a low-fat diet.xx xxi xxii xxiii xxiv xxv xxvi xxvii xxviii xxix Orally, beta-sitosterol is usually well tolerated. Ezetimibe (Zetia), a medication used to lower cholesterol levels, inhibits intestinal absorption of beta-sitosterol. For most people, 800-2000 mg beta-sitosterol, in divided doses taken before meals, is a good amount.

Similar to sterols, plant stanols are natural substances that occur in even smaller quantities in many of the same sources. Like sterols, stanols block the absorption of cholesterol in the intestines. One stanol, sitostanol, has been extensively researched for its effect upon cholesterol. Specifically, taking sitostanol orally is effective for reducing total and LDL- cholesterol in about 88% of adult patients when used alone or in combination with a low-fat diet or statin drug (drug that inhibits the production of cholesterol in the body).xxx xxxi xxxii xxxiii xxxiv xxxv xxxvi xxxvii xxxviii xxxix xl xli xlii xliii xliv xlv When used alone it can reduce total and LDL cholesterol levels by 10% to 15%. When added to statin drugs, sitostanol reduces total cholesterol and LDL cholesterol by an additional 3% to 11% and 7% to 16%, respectively. Clinical studies have used from 800 mg to 4 grams per day.xlvi The best cholesterol lowering effects occur at about 2 grams per day, but doses above 2 grams per day do not seem to provide additional benefit.xlvii Sitostanols are not currently found in dietary supplements, but they can be found in certain margarine-type spreads and salad dressings. Read product labels in your supermarket and see which of these products provide sitostanol. Orally, sitostanol seems to be very well tolerated. Sitostanol can reduce absorption and blood levels of beta-carotene, so it should be used at a different time if you are taking beta-carotene supplements. For best results, use 2000 mg sitostanol in divided doses taken before meals.

Green Tea Leaf Extract

Although made from the leaves of the same plant that brings us ordinary black tea, green tea differs in that it is less fermented and so contains far more polyphenol catechins and theaflavins, natural ingredients that give green tea its medicinal properties. In double-blind research, green tea extract (GTE) taken orally lowered cholesterol and triglycerides. In one such study the GTE group had significant reduction in LDL-cholesterol and triglyceride, and marked increase in the level of HDL-cholesterol from 1200 mg GTE daily.xlviii In another study, a 10% decrease in systolic blood pressure and a 9% reduction in LDL cholesterol was seen with 583 mg of catechins from GTE compared to no change is systolic blood pressure and a 1% increase in LDL cholesterol in the control group.xlix Likewise, a 375 mg daily of a theaflavin-enriched GTE resulted in an 11.3% reduction in total cholesterol, a 16.4% deduction in LDL-cholesterol, and a 2.3% increase in HDL-cholesterol, while cholesterol levels did not change significantly in the placebo group.l Epidemiological research also indicates that adults who consume 6 or more cups/day of green tea have a 33% lower risk of developing type 2 diabetes compared to those who consume one cup/day or less.

High doses of green tea extract may cause gastrointestinal upset and/or central nervous system stimulation in some people. Theoretically, the caffeine in green tea might increase the risk of additive CNS effects with amphetamines, although GTE only provides about 10 to 30 mg of caffeine (compared to 100 mg in a cup of moderately brewed coffee). Catechins in green tea and caffeine are reported to have antiplatelet activity, so theoretically green tea might increase the risk of bleeding when used with antiplatelet or anticoagulant drugs (although this interaction has not been reported in humans). The doses used in research ranged between 375 to 1200 mg of GTE. Consuming 375 mg of green tea extract (providing 60% polyphenols) would be equivalent to drinking about 6-8 cups of green tea.

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