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CSU researchers discover three new feline viruses, raising questions about transmission and disease

Jan 29th 2014 at 10:06 PM



Pathogen researchers at Colorado State University have discovered a family of cancer-causing viruses in several U.S. populations of bobcats, mountain lions and domestic cats, raising questions about whether the previously undetected viruses could be transmitted between cat species - and whether they might be the root cause of some cancers found in housecats.

Scientists tested nearly 300 individual blood samples from cats in three geographic regions in Florida, Colorado and California. They found significant numbers of each species infected, indicating widespread distribution of the newly identified viruses, said Dr. Susan VandeWoude, a research veterinarian and associate dean in the CSU College of Veterinary Medicine and Biomedical Sciences. Much of the work was conducted in her laboratory.

The newly identified viruses are in the same family of gammaherpesviruses that can cause lymphoma and Kaposi's sarcoma in people, especially those with HIV-AIDS and other immune-suppressing conditions. Both are cancers of the circulatory system.

Other herpesviruses can cause fatal bovine disease when transmitted to cattle from host species, including wildebeest and sheep.

It is not yet known whether the novel feline viruses are associated with diseases in bobcats, mountain lions and pet cats, but the link between gammaherpesviruses and disease in other species clearly raises the possibility, scientists said.

"We think there's a chance these viruses could be doing something similar in cats," said Ryan Troyer, a research scientist in CSU's Department of Microbiology, Immunology, and Pathology. "Discovery of viruses and virus transmission is important because it can help us understand common and emerging diseases in animals and people. That's the first step to stopping infectious disease."

The research findings were published in the online version of the Journal of Virology. Among those on the research team is Julia Beatty, an expert in feline disease at the University of Sydney, Australia, who helped design the investigation during a visit to the CSU campus.https://plus.google.com/u/0/b/102913432323563044867/102913432323563044867/posts

Collaborators were able to identify gammaherpesviruses in bobcats, mountain lions and domestic cats after developing techniques to rapidly and specifically detect the virus DNA in feline blood, the research paper reports.

Wildlife ecologists collected blood samples from the bobcats and mountain lions in the course of separate studies related to the wild cats; they shared samples for the CSU study. Likewise, animal shelters across the United States collected and shared blood samples from domestic cats.

The study populations were near Los Angeles and San Diego, Calif.; Fort Myers and Naples, Fla.; and Montrose and Grand Junction on Colorado's Western Slope.

In analyzing blood collected from wild and domestic cat populations in these regions, researchers identified the novel gammaherpesviruses in three species - and further discovered the bobcat virus in some mountain lions. The route of transmission remains unknown, but could occur when the animals fight in the wild, Troyer said.

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CSU researchers discover three new feline viruses, raising questions about transmission and disease

Jan 29th 2014 at 10:25 PM

Pathogen researchers at Colorado State University have discovered a family of cancer-causing viruses in several U.S. populations of bobcats, mountain lions and domestic cats, raising questions about whether the previously undetected viruses could be transmitted between cat species - and whether they might be the root cause of some cancers found in housecats.

Scientists tested nearly 300 individual blood samples from cats in three geographic regions in Florida, Colorado and California. They found significant numbers of each species infected, indicating widespread distribution of the newly identified viruses, said Dr. Susan VandeWoude, a research veterinarian and associate dean in the CSU College of Veterinary Medicine and Biomedical Sciences. Much of the work was conducted in her laboratory.  https://app.box.com/s/qm8ewbt0o855yr59scha

The newly identified viruses are in the same family of gammaherpesviruses that can cause lymphoma and Kaposi's sarcoma in people, especially those with HIV-AIDS and other immune-suppressing conditions. Both are cancers of the circulatory system.

Other herpesviruses can cause fatal bovine disease when transmitted to cattle from host species, including wildebeest and sheep.

It is not yet known whether the novel feline viruses are associated with diseases in bobcats, mountain lions and pet cats, but the link between gammaherpesviruses and disease in other species clearly raises the possibility, scientists said.

"We think there's a chance these viruses could be doing something similar in cats," said Ryan Troyer, a research scientist in CSU's Department of Microbiology, Immunology, and Pathology. "Discovery of viruses and virus transmission is important because it can help us understand common and emerging diseases in animals and people. That's the first step to stopping infectious disease."

The research findings were published in the online version of the Journal of Virology. Among those on the research team is Julia Beatty, an expert in feline disease at the University of Sydney, Australia, who helped design the investigation during a visit to the CSU campus.

Collaborators were able to identify gammaherpesviruses in bobcats, mountain lions and domestic cats after developing techniques to rapidly and specifically detect the virus DNA in feline blood, the research paper reports.

Wildlife ecologists collected blood samples from the bobcats and mountain lions in the course of separate studies related to the wild cats; they shared samples for the CSU study. Likewise, animal shelters across the United States collected and shared blood samples from domestic cats.

The study populations were near Los Angeles and San Diego, Calif.; Fort Myers and Naples, Fla.; and Montrose and Grand Junction on Colorado's Western Slope.

In analyzing blood collected from wild and domestic cat populations in these regions, researchers identified the novel gammaherpesviruses in three species - and further discovered the bobcat virus in some mountain lions. The route of transmission remains unknown, but could occur when the animals fight in the wild, Troyer said.

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