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Debbie Evans | cdgenomics

Comparative Study on the Function of Genome Regulation by Epigenomics Method

Dec 17th 2015 at 1:41 AM

Human genome sequencing has produced a large number of genetic information, but the understanding of the function of each gene has not been achieved. In a new study, researchers at the University of Illinois reported that a new method called "comparative epigenomics" was used to identify genes function. The results of the study were published in the journal Cell on June 8, 2012.

"Comparative genomics is a comparison between DNA and histone modifications," said a researcher at the Institute of biological engineering and genomics at the Illinois University."

Although the genome of an organism contains all its genes, it is in fact determined by genes expressed in the genome. Although it has long focused on comparative genomics—the comparison of the genome in similar species, the comparative epigenomics provides a more in-depth understanding of the regulation function.

Researchers from University of Washington, Harris Lewin and Franklin West Harris from the University of Georgia conducted research. They focused on three species: human, mouse and pig. By analyzing the 9 epigenetic markers and pluripotent stem cell, they were able to construct a table view genome map for each species.

The research team concluded that as long as the appropriate analysis procedures were taken, people could be able to identify the species with a conservative marker of the species. They then confirmed that the conservative epigenetic markers could be effectively used to label the genome and to elucidate the regulatory function of the genome.

Many diseases, such as sickle cell anemia, thalassemia, cystic fibrosis are related to genetic information. Common diseases often have multiple causes, which are often caused by multiple genes and environmental factors.

One of the most pressing issues for science is to understand the science of genomics, which reveals a promising alternative. "A comparative study of the concept of genomics allows us to find more clues about the evolution of our genome".

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