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Common antidepressant gives hope for slowing Alzheimer's

May 15th 2014 at 9:08 PM

A widely used antidepressant drug citalopram, may in future be used in the fight against Alzheimer's disease, as well as tests in humans and animals raise hopes that might slow down the symptoms of the neurodegenerative disease, for which so far there is no cure. Scientists although marked "encouraging" discovery, said that it is too early to get people antidepressants just to slow dementia. Other experts featured "interesting" finding strength and felt that the drug is already approved - albeit for other use

.Researchers of Medical Faculties of the Universities of Pennsylvania and Washington, led by professor of psychiatry Yvette Silain, made ​​after publication in the medical journal "Science Translational Medicine", according to the BBC, granted that substance in 23 humans and mice. Scientists found that citalopram inhibited the activity of a protein, amyloid beta, which-together with the T-protein contributes creating destructive

"plaques" in the brains of Alzheimer's patients, damaging vital neurons and causing various problems (memory, reasoning, mood, communication, etc.). The level of beta-amyloid was decreased by 25% in mice with disease, who had taken the drug. After two months of treatment, the rate of development of new plaques in their brains had declined significantly (to 78%), while the existing plates do not grow anymore. But there was no shrinkage in the size of existing plaques or reduce their number.

The 23 healthy volunteers, aged 18 to 50 years old, got only one dose of citalopram (60 milligrams) and the level of amyloid beta in the spinal fluid fell by 38% within 37 hours after dosing. 's Silain admitted that "we are still far from being able to assure that these antidepressants may prevent cognitive decline associated with Alzheimer's disease.

" He however optimistic that probably the drug could slow the progression of the disease in ten to fifteen years before the symptoms become more visible. One of the researchers, the assistant professor of neurology John Ciric said that "although antidepressants are generally well tolerated, have risks and side effects.

Until it we can prove without doubt that they actually help to slow or stop Alzheimer's in humans, not worth risking it. We also do several investigations. ' will follow a new study to determine whether citalopram may act protective over time. A future large clinical trial, which will last several years, we also compare the efficacy of the drug compared to a placebo (placebo). investigations chief of the British Society of disease appeared skeptical, saying the sample was small and did not include patients with Alzheimer's

or people over 50 years, in which the disease occurs mainly. Citalopram, adopted in 1998 by the competent supervisory authority of the Food and Drug Administration (FDA) USA, belongs to the category of 'selective serotonin reuptake inhibitors »(SSRI), the Most new "generation" antidepressants. Serotonin is a key neurotransmitter in the brain, chemists 'carriers' messaging. For the original scientific paper (with subscription) at:

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