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Advanced Development of Antibodies

Apr 21st 2020 at 12:44 AM

Antibodies play a crucial role in the body. These are the protective proteins that is produced in the body. The antibodies are usually produced in response to the invasion of the antigens in the respective body. The antigens manipulate the normal functioning of the body and affect the tissues along with the organs. The immune system itself produces the antigens in the body. The shape of the antibodies is usually Y-shaped. It comprises of N-terminus and C-terminus. The two types of chains present in the antibody are light and heavy chains. Covalent conjugation FITC is combined with the respective immunoglobulin’s primary amines that are also known as lysins. The FITC is an organic molecule that binds to the proteins. Goat anti-llama FITC is a popular antibody that is used in the research field across the world. It is the secondary antibody that falls under the category of polyclonal antibody.


The best part of this antibody is that it recognizes both heavy and light chains. One of the advanced techniques that are used in the antibody production is that of recombinant antibody technology. An innovative method that is used in the research labs is the Human Combinatorial Antibody Library (HuCAL). Here, a wide range of human antibody specificities are taken into reference. The technology is used in the field of research along with in vitro diagnostic applications. The generation time of the polyclonal antibodies is 3 to 4 months when compared to other types of antibodies. The specificity of this antibody cannot be controlled. There is the presence of batch to batch variability in case of the antibodies.

Custom antibody development is in high demand in the present times due to its interest and importance. Researchers in the pharmaceutical companies are finding out the significance of these advanced processes. Usually, the polyclonal antibodies comprise a mixture of IgG antibodies. These antibodies detect the presence of multiple epitopes on the antigen. The use of custom antibodies is in the field of biopharmaceutical and life science-based firms.


The development of the antibodies is done under the expertise of the scientists who are constantly studying, researching, and introducing new aspects of the antibodies. In most of the cases, synthetic peptides are used for the developing the antibodies as per the requirements of the concerned purpose or company. These peptides include phosphor or acetylated peptides, gel-eluted proteins, and recombinant proteins. The quality of the custom antibody development is a crucial aspect of the research sector. In some of the cases, monoclonal and polyclonal antibodies are developed based on the requirements of the respective organization. Thus, diverse types of antibodies are useful in the research sector to find out various aspects of the antibodies and their uses in the chosen segment.

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