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Study To Improve Treatments For Muscular Dystrophy - Kyle Leon Review
About two-thirds of cases occur in families with a history of the disease a genetic defect in charge is passed from mother to son - but about one-third of cases occur spontaneously.
This is because the roots of this disease lies in the genetic defect in the gene responsible for making a large protein, which helps make and keep muscles strong and stable.
Weighing in at 2 million chemical bases is the largest gene in the human body, and mutations are relatively frequent. In patients with a mutation, the body does not make enough and muscle fibers are gradually replaced with fatty tissue, and others.
In a study of more than 20 years ago, in studies supported by the Muscular Dystrophy Association, Griggs and colleagues found that taking a daily dose of life of patients improves prednisone "dramatically. Has found after Griggs treatment of muscular dystrophy chaos because of concerns about side effects. For More Read this By Kyle Leon Review
In a recent study of more than 100 centers worldwide that specialize in the treatment of this disease, there were only three using the recommended treatment has always been - a daily dose of prednisone. Others using prednisone intermittently or were not at all using steroids.
In the new study will be patients were randomly assigned to receive treatment and one of the three steroids: a) prednisone every day; b) prednisone every day for 10 days, alternating with periods for 10 days without drugs; c) daily use of a steroid, which was approved for use in Europe but not the United States. Patients will not be able nor researchers are aware of assignments and treat patients until the end of the trial.
The doctors found that daily prednisone boosts muscle strength dramatically and that the effects felt by patients and witnessed by parents within just 10 days.
Drug enhance muscle mass by 20 percent and slows muscle atrophy in patients who suffer from this disease. But fears of side effects leave a lot of doctors leery of prescribing the medicine on a daily basis. Side effects can include weight gain, behavioral effects such as hyperactivity or irritability, and eventually loss of bone fractures and possibly even.
"People have worried about side effects of prednisone daily, and many people feel there must be a better alternative," said Griggs, a professor of Neurology, Medicine, Pediatrics, Pathology and Laboratory Medicine, and a member of the Center for Human Rights Therapeutics pilot. "Our study was designed to address exactly this question: What is the best balance between effective treatment and side effects?"
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