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Big Steps To Fight Deadly Childhood Muscle Cancer - Kyle Leon Muscle Building Program
The disease, named alveolar rhabdomyosarcoma, "is a very mean childhood cancer," says study leader Mario Capecchi, co-chair of human genetics at the University School of Medicine and an investigator with the Howard Hughes Medical Institute . "Once the cancer has spread, and 80 percent of children are likely to die within five years, and even with the most aggressive treatment possible, including surgery, chemotherapy and radiation." Article Research By Kyle Leon Program
Capecchi says the studies as evidence that cancer may arise in the skeletal muscle fibers mature or nearly mature. This is controversial because the stem cells Moon - cells that become new muscle - long have suspected leading to rhabdomyosarcoma.
"If we know where to start, and why, you may be able to prevent it, early detection, or the development of new therapies based on a better understanding of the biology of the tumor," says Charles Keller, a specialist pediatric cancer and the first author of this study.
During the past 30 years, "there have been significant improvements in cure rates for a number of cancers," he adds. "However, it has been the result of alveolar rhabdomyosarcoma advanced to pretty much the same for 30 years."
Until now, scientists have been unable to breed mice with alveolar rhabdomyosarcoma, so "we understand the initiation and development of the disease is very weak," says Keller.
"This work represents a major step forward in understanding this disease, and puts us on the path toward new therapies" less toxic to patients and better aimed at the cancer.
Keller and we believe that it is still Capecchi will take 10 to 20 years for new treatments to emerge. But, Keller adds: "After 30 years of limited progress, we have our feet in the door."
Will be published new studies in the journal Genes & Development, with one of the studies, published online on Oct. 15. The use of these studies involved mice, which has a genetic makeup quite similar to humans, and therefore as "models" for the study of human diseases.
The co-authors of the studies, the University of Utah undergraduate Mark Hansen; Cheryl Coffin, a physician at the Pediatric; Benjamin Arenkiel, a graduate student in human genetics, and Nabil Harvard Medical School in Sharm,Bardeesy, DePinho and Ronald.
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