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Teratment For Overweight: Liraglutide (Saxenda)

Dec 31st 2018 at 8:44 PM

What Is Saxenda (Liraglutide)?

Saxenda can be an injection that's already for sale in a lower dose as another drug, Victoza, which consequently is used for its treatment of type 2 diabetes. It belongs to a category of drugs called biochemically as glucagon-like peptide-1 (glp 1 ) receptor agonists. Another drug in this category features exenatide (Byetta). While most are used for erectile dysfunction, liraglutide (in its dose as Saxenda) may be the very first ever to get FDA approval designed for weight management.

For Whom Is Saxenda Intended?

Saxenda continues to be approved for use in adults with a body mass index (BMI) of 30 or more or in adults with a BMI of 27 or greater who have at least one other weight-related disease, like diabetes, higher blood pressure, or high cholesterol.

Moreover, Saxenda is meant to be utilised as an adjunct to diet and exercise to get chronic weight management in adults. It is perhaps not meant to replace exercise and diet.

Its Effectiveness

3 clinical trials have assessed the safety and effectiveness of Saxenda. These trials registered approximately 4,800 obese and overweight patients in total. 1 clinical trial which examined patients with diabetes found an average weight loss of 4.5% in the patients who obtained Saxenda. This trial also found that 62 percent of people have been medicated with Saxenda lost at least 5 percent of their own body weight. You may buy Saxenda Online for effective weight loss.

In a second clinical trial which looked at patients having type two diabetes, results demonstrated that those treated with Saxenda lost 3.7percent of their weight when compared with treatment with placebo, and 49% of those carrying Saxenda lost atleast 5% of their body weight (compared to just 16% of people taking placebo).

Ergo, it appears that Saxenda may be slightly more effective for fat loss inpatients who do not need type 2 diabetes, even though it still had a direct effect--a younger one--on weight control for those with diabetes.

What Are the Negetive Effects?

The FDA has already issued a black box warning on Saxenda, saying that tumors of the thyroid gland have been detected in studies in rodents, however that it's not known whether or not Saxenda may cause these microbes in humans.

Serious negative effects which were reported in patients taking Saxenda include pancreatitis (inflammation of the pancreas, which can be life-threatening), gallbladder disease, kidney disease, and suicidal thoughts. Additionally, Saxenda can raise heartbeat, and also the FDA advises that is be discontinued in any patient who undergoes a sustained growth in resting heart rate.

The most frequent side effects of Saxenda which were found in the clinical trials were nausea, constipation, vomiting, diarrhea, decreased appetite, and low blood glucose levels (hypoglycemia).

Who Would Not Take Saxenda?

Due to the theoretical threat of thyroid tumors, Saxenda must not be taken by patients using a rare endocrine disorder known as multiple endocrine neoplasia syndrome type 2 (MEN-2), or by patients with a family or personal history of a kind of thyroid cancer called medullary thyroid carcinoma (MTC).

 

Others who must not take Saxenda comprise: children (the FDA is now requiring clinical trials to evaluate the efficacy and safety of children), women who are pregnant or breastfeeding, and anyone who has ever had a severe hypersensitivity reaction to liraglutide or into any one of the product components of Saxenda.

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